"Blue Eyes Bio supplies cGMP-compliant L-Proline (CAS 147-85-3) meeting Ph.Eur./USP/JP standards. Critical for collagen matrix formation in advanced wound care, joint health therapies, and cosmeceutical actives
Blue Eyes Biotech Co., Ltd: Premium L-Proline Manufacturer
Company Overview
Blue Eyes Biotech Co., Ltd is a global leader in pharmaceutical-grade L-Proline production through advanced microbial fermentation technology. Headquartered in the UK with state-of-the-art Asian facilities, Blue Eyes Biotech Co., Ltd supplies ultra-pure L-Proline to pharmaceutical, nutraceutical, and cosmeceutical industries across 45+ countries.
Product Excellence
Blue Eyes Biotech Co., Ltd's L-Proline features:
1. ≥99.8% purity (USP/EP/JP compliant)
2. Halal/Kosher/Vegan certifications
3. Heavy metal content <3ppm
4. Exceptional formulation stability
Parameter | Specification | Test Method |
Appearance | White crystalline powder | EP 2.2.1 |
Assay (HPLC) | ≥99.5% | USP <621> |
Specific Rotation | -84.5° to -86.5° | EP 2.2.7 |
pH (5% Solution) | 5.5-6.5 | Potentiometric |
Loss on Drying | ≤0.2% | EP 2.2.32 |
Residue on Ignition | ≤0.05% | USP <281> |
Heavy Metals (Pb) | ≤2 ppm | ICP-MS (ICH Q3D) |
Proline-Related Impurities | ≤0.1% total | UPLC (Validated) |
Endotoxins | <0.1 EU/mg (Cell Therapy Grade) | USP <85> |
Transmittance | ≥99.0% (430nm) | EP 2.2.25 |
Oxoproline Limit | ≤0.05% | LC-MS/MS |
3. Core application scenarios
Regenerative medicine field
- Wound repair preparations
✓ Core substrate for collagen synthesis (type III collagen inducer)
✓ Key ingredient for diabetic ulcer gel
- Bone and joint health
✓ Cartilage matrix precursor (synergistic with glycine)
✓ Excipient for joint injection
High-end functional skin care products
- Anti-aging active ingredients
✓ Stimulate fibroblasts (clinical data: collagen synthesis ↑300%)
✓ Reduce photoaging wrinkles (1% concentration percutaneous absorption)
- Postoperative repair products
✓ Microneedle/laser postoperative regeneration promoter
Biotechnology
- Key components of stem cell culture medium (increase clone formation rate)
- Viral vector stabilizer (AAV gene therapy)
4. Compliance system (regenerative medicine focus)
Innovative Production
Blue Eyes Biotech Co., Ltd utilizes:
- Proprietary non-GMO bacterial strains
- Membrane crystallization systems
- HPLC-MS/MS analysis
- Zero-waste processes
Key Applications
Blue Eyes Biotech Co., Ltd's L-Proline is essential for:
1. Skincare: Collagen synthesis
2. Sports nutrition: Joint recovery
3. Cardiovascular therapies
4. Cell culture media
Quality Assurance
Every batch of L-Proline from Blue Eyes Biotech Co., Ltd undergoes:
- Endotoxin testing (<0.02 EU/mg)
- Pyrogen analysis
- Full traceability
- COA certification
Global Supply
Blue Eyes Biotech Co., Ltd provides:
- 15,000-ton annual capacity
- Guaranteed lead times
- Custom formulations
- Technical support
As a regenerative medicine proline supplier, we ensure ultra-low oxoproline levels for cell therapy applications with full ICH Q3D compliance.
A: Our cryo-milled grade (D50=8μm) enhances transdermal delivery. Penetration data shows 42% bioavailability vs standard 18%.
Q: Is proline suitable for cartilage tissue scaffolds?A: Yes, supplied to 3 EU tissue engineering companies for collagen-hyaluronic acid composites. Request scaffold compatibility data.